Publications

Publications
10.
Structurally heterogeneous ribosomes cooperate in protein synthesis in bacterial cells.
Helena-Bueno K, Kopetschke S, Filbeck S, Chan LI, Birsan S, Baslé A, Hudson M, Pfeffer S, Hill CH, Melnikov SV (2025).
Nature Communications, 16:2751 Link
9.
Evolution of drug-binding residues in eukaryotic ribosomes.
Chan LI, Ekemezie CL, Brown CR, Helena-Bueno K, Williams T, Melnikov SV (2024).
bioRxiv. PDF
8.
Evolution of drug-binding residues in bacterial ribosomes.
Ekemezie CL, Chan LI, Brown CR, Helena-Bueno K, Williams T, Melnikov SV (2024).
bioRxiv. PDF
7.
Hibernating ribosomes as drug targets?
Ekemezie CL, Melnikov SV (2024).
Review – Frontiers in Microbiology, 2024:1436579. PDF
6.
Rippling life on a dormant planet: hibernation of ribosomes, RNA polymerases and other essential enzymes.
Helena-Bueno K, Chan LI, Melnikov SV (2024).
Review – Frontiers in Microbiology, 15:1386179. PDF
5.
Gosha: a database of organisms with defined optimal growth temperatures.
Helena-Bueno K, Brown CR, Konyk E, Melnikov SV (2024).
bioRxiv. PDF
4.
The structure of dormant bacterial ribosomes reveals an elusive hibernation factor of protein synthesis.
Helena-Bueno K, Rybak MYu, Ekemezie CL, Sullivan R, Brown CR, Dingwall C, Baslé A, Schneider C, Connolly JPR, Blaza JN, Csörgő B, Moynihan PJ, Gagnon MG, Hill CH, Melnikov SV (2024).
Nature, 626:1125–1132. PDF
3.
A conserved ribosomal protein has entirely different structures in different organisms.
Schierholz L, Brown CR, Helena-Bueno K, Uversky VN, Barandun J, Melnikov SV (2023).
Molecular Biology and Evolution, 41:msad254. PDF
2.
Ribosomal proteins hold a more accurate record of thermal adaptation compared to rRNA.
van den Elzen A, Helena-Bueno K, Brown CR, Chan LI, Melnikov SV (2023).
Nucleic Acids Research, 51:8048–8059. PDF
1.
“Lose-to-gain” adaptation to genome decay in the structure of the smallest eukaryotic ribosomes.
Nicholson D, Salamina M, Panek J, Helena-Bueno K, Brown CR, Hirt RP, Ranson NA, Melnikov SV (2022).
Nature Communications, 13:591. PDF | SI