I want this in purple

There is one principle taught in business schools that struggles to find footing in the world of academic publishing: convergent feedback.

In business, if you create a product and 9 out of 10 people tell you the handle is too small or the color is wrong, you fix it and try again. But if 9 out of 10 say it’s good and they’re buying it, you quickly scale up your production and give your business a chance to thrive. In academic publishing, however, the idea of convergent feedback usually seems foreign:

When you submit a manuscript and receive feedback from three reviewers, you often find zero convergent feedback: one reviewer finds everything acceptable but feels that the font must be changed to purple—”it looks better on white.” Another has not problems with the font color but argues your work should be rewritten in the form of haiku poetry, not a lengthy prose. The third dismisses both font and poetry as non-issues yet demands you replace all long words with short ones (they studied Hemingway in grad school).

In STEM, requested revisions are much harder to address: a single reviewer can mandate months of costly, exhaustive experiments, which may involve developing entirely new methods or introducing new model organisms. Sometimes, these experiments are essential to justify your claims or exclude experimental artifacts. But sometimes you do all this work just to replicate some previous experiments and findings. Or worse—just to satisfy a subjective whim: “I want this text in purple”.

So here we go: you make your text in purple—which other reviewers find odd. You also change the words to shorter ones—although many of them do not rhyme very well. And you delete a few essential blocks of text because they do not fit haiku. And then you resubmit. The work now looks somewhat odd, but everyone is happy: the reviewers are pleased you took time to understand their comments and address them obediently; the editor is happy the reviewers are happy. You are now okay to proceed to publishing your work that looks like Greek chimera—after someone young in your lab just spent several precious months of their life in this exercise, where the quest for scientific excellence is mixed with an unhealthy dose of unadulterated people-pleasing.

On a practical side, there is a good solution to this. As writers, we can now publish our work as a preprint—where we can express our ideas and findings as is and without needless delays. And as reviewers, we can always ask: ” Are my requests essential—or will they just add months of work for needless polishing?” We can also kindly reject work that lacks merit, where findings are not novel or conclusions are not justified—but we must, as a community, stop this unhealthy habit of demanding needless perfectionism. We need to stop this unhealthy habit of looking at solid studies– and requesting more experiments just for the sake of this ingrained tradition of asking for more.

Odds of being alive

Every time I hear people ranting about life being unfair, huffing and puffing if things don’t go their way, I recall this stunning visual: “What are the odds”. It estimates our odds of being alive, showing they are just a fraction above zero, or 1 in 102,685,000 if you like math.

Imagine: 1 in 102,685,000. As someone put it, “that probability is the same as if you handed out 2 million dice, each dice with one trillion sides… then rolled those 2 million dice and had them all land on 439,505,270,846.” It seems we are damn good at gambling! At least for once. So, when next time your dumb classmate gets into Harvard and you fail as a valedectorian, please recall this absurdly slim chance of your existance, and take a moment to appreciate this unique gift of luck — to be alive as a concious human being, to share this transient journey we call life with people we love, to get a chance to understand and explore ourselves and the universe around us, to breath air and enjoy warm rays of the morning Sun — all those things we take for granted while being obsessed with the cherry on top. Because, if scientists got it right, our life is highly improbable, and it won’t last for long. Thus, luckily for us, life is tremendously unfair, if you see what I mean.

Integrated bug management

In late 1970s, agriculture encountered a major crisis in pesticide resistance leading to the near-collapse of the cotton industry in several countries. This crisis forced the industry to devise the Integrated Pest Management (IPM), an approach that aims to minimize the risk of pesticide resistance by limiting pesticide use and by trying to manage pests rather than trying to eradicate them. Our recent paper provides a small “stone” for the emerging “building” of a similar approach – adaptive therapy – that aims to improve the way use antimicrobial and anticancer drugs: https://www.pnas.org/content/early/2020/07/10/2003132117

Please check out this wonderful blog post by Maria O’Hanlon discussing our work and this emerging new trend in more sustainable drug application: https://bit.ly/3fs45sr