Melnikov Lab

Pubs

2025

  • The evolutionary lifecycle of ribosome hibernation factors
    Chan LI, Omae K, Brown CR, Amikura K, Ekemezie CL, Clark J, Nishide K, Helena-Bueno K, Palmowski P, Porter A, Suzuki S, Melnikov SV
    bioRxiv 2025.11.04.686544

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  • Translon: a single term for translated regions
    Świrski MI, Tierney JAS, Albà MM, Andreev DE, Aspden JL, Atkins JF, Bassani-Sternberg M, et al.
    Nature Methods 22(10), 2002–2006

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  • Evolution of drug-binding residues in eukaryotic ribosomes
    Chan LI, Ekemezie CL, Brown CR, Helena-Bueno K, Williams TA, Melnikov SV
    Cell Reports 44(9), 116244

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  • Extensive natural variation in bacterial ribosomal drug-binding sites
    Ekemezie CL, Chan LI, Brown CR, Helena-Bueno K, Williams TA, Melnikov SV
    Cell Reports 44(7), 115878

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  • Structurally heterogeneous ribosomes cooperate in protein synthesis in bacterial cells
    Helena-Bueno K, Kopetschke S, Filbeck S, Chan LI, Birsan S, Baslé A, Hudson M, Pfeffer S, Hill CH, Melnikov SV
    Nature Communications 16, 2751

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2024

  • Rippling life on a dormant planet: hibernation of ribosomes, RNA polymerases, and other essential enzymes
    Helena-Bueno K, Chan LI, Melnikov SV
    Frontiers in Microbiology 15, 1386179

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  • Engineered mRNA–ribosome fusions for facile biosynthesis of selenoproteins
    Thaenert A, Sevostyanova A, Chung CZ, Vargas-Rodriguez O, Melnikov SV, Söll D
    PNAS 121(11), e2321700121

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  • A new family of bacterial ribosome hibernation factors
    Helena-Bueno K, Rybak MY, Ekemezie CL, Sullivan R, Brown CR, Dingwall C, Baslé A, Schneider C, Connolly JPR, Blaza JN, Csörgő B, Moynihan PJ, Gagnon MG, Hill CH, Melnikov SV
    Nature 626(8001), 1125–1132

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  • tRNA shape is an identity element for an archaeal pyrrolysyl-tRNA synthetase from the human gut
    Krahn N, Zhang J, Melnikov SV, Tharp JM, Villa A, Patel A, Howard RJ, Gabir H, Patel TR, Stetefeld J, Puglisi J, Söll D
    Nucleic Acids Research 52(2), 513–524

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  • A conserved ribosomal protein has entirely dissimilar structures in different organisms
    Schierholz L, Brown CR, Helena-Bueno K, Uversky VN, Hirt RP, Barandun J, Melnikov SV
    Molecular Biology and Evolution 41(1), msad254

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2023

  • Ribosomal proteins can hold a more accurate record of bacterial thermal adaptation compared to rRNA
    van den Elzen A, Helena-Bueno K, Brown CR, Chan LI, Melnikov SV
    Nucleic Acids Research 51(15), 8048–8059

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2022

  • Adaptation to genome decay in the structure of the smallest eukaryotic ribosome
    Nicholson D, Salamina M, Panek J, Helena-Bueno K, Brown CR, Hirt RP, Ranson NA, Melnikov SV
    Nature Communications 13, 591

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2021

  • Gosha: a database of organisms with defined optimal growth temperatures
    Helena-Bueno K, Brown CR, Melnikov SV
    bioRxiv 2021.12.21.473645

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  • Bacterial translation machinery for deliberate mistranslation of the genetic code
    Vargas-Rodriguez O, Badran AH, Hoffman KS, Chen M, Crnković A, Ding Y, Krieger JR, Westhof E, Söll D, Melnikov SV
    PNAS 118(35), e2110797118

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