Data

Studying protein adaptation to heat and cold through comparative analysis of thousands of genomes.

Genome sequences hot and cold: a database of organisms with experimentally defined optimal growth temperatures.

If you are interested in exploring the adaptation of biological molecules and organisms to new environments, then this database is for you. And if you are interested in designing biological molecules or organisms with the desired tolerance to heat and cold, this website was developed for you too.

Download data
These datasets describe bacteria, archaea, and eukaryotes with experimentally defined optimal growth temperature and genomic sequences deposited in the NCBI genome database:
Download bacterial species (14,344 species)
Download bacterial genera (3,100 genera)
Download species (Y species)
Download genera (340 genera)
Download species (X species)
Download genera (3,980 genera)

Check the growth temperature (script 1)

Enter your organisms name and check its optimal growth temperature: (here will be the input form for script 1)

Retrieve sequences of your protein of interest (script 2)

Enter your protein name (as listed at Uniprot) and retrieve its sequences arranged by the optimal growth temperature of corresponding organisms (here will be an input form for the second script)